If you have ever asked this question in an interview, you are not alone! But that doesn’t make it a good question. In fact, it will probably get you canned answers, break rapport and you won’t actually learn anything useful. Try asking something about challenges and triumphs instead, and then listen for weaknesses as you define them. Weaknesses and strengths go together and may be mirror images of the same traits. They are certainly dependent on the situation and your personal experience and point of view.